Naloxone dosing follow-up: If respiratory rate remains <12 after initial Narcan.

• A. every 2 minutes, max 15 mg
• B. every 1 minute, max 10 mg
• C. every 5 minutes, max 5 mg
• D. only once

Answer: (B)

The main idea is to titrate naloxone to restore breathing by giving small, repeat doses and reassessing quickly. If the patient’s respiratory rate stays below 12 after the initial Narcan, you continue dosing at short intervals so you can judge response promptly and avoid over- or under-reversal. The recommended approach uses a 1-minute interval for each additional dose and caps the total amount at 10 mg. This balance helps rapidly reverse opioid-induced respiratory depression while reducing the risk of precipitating withdrawal or causing withdrawal-like agitation, and it accounts for scenarios where the opioid effect could re-emerge as naloxone wears off. If there’s still poor ventilation after reaching the maximum or after several doses, prioritize airway support and further medical management.